mitochondrial metabolism — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T9372	D-Histidine		Mitochondrial Metabolism
	D-Histidine is an enantiomer of L-histidine. L-Histidine is an inhibitor of mitochondrial glutamine transport and also an essential amino acid for infants.		Mitochondrial Metabolism
TN1586	Dihydrorotenone		Apoptosis , Mitochondrial Metabolism
	Dihydrorotenone is a potent mitochondrial inhibitor and probably induces Parkinsonian syndrome.		Apoptosis , Mitochondrial Metabolism
T8433	HQNO		Mitochondrial Metabolism
	HQNO is a natural product isolated from P. aeruginosa,and is a potent inhibitor of electron transport chain(Kd of 64 nM for complex III). It also is a potent mitochondrial NDH-2 inhibitorin many species.		Mitochondrial Metabolism
T15373	Gboxin		ATPase , Mitochondrial Metabolism
	Gboxin is an inhibitor of oxidative phosphorylation that targets glioblastoma,inhibits the activity of F0F1 ATP synthase, with antitumour activity.		ATPase , Mitochondrial Metabolism
T9777	THP104c		Mitochondrial Metabolism
	THP104c is an inhibitor of mitochondrial fission.		Mitochondrial Metabolism
T12408	Perhexiline maleate		Others , Mitochondrial Metabolism
	Perhexiline maleate is an orally active inhibitor of CPT1 and CPT2 that reduces fatty acid metabolism. The IC50 values of perhexiline maleate against rat heart and liver CPT 1 were 77 and 148 μM, respectively.		Others , Mitochondrial Metabolism
T1768	7ACC2		Mitochondrial Metabolism , Monocarboxylate transporter
	7ACC2 is a new potent MCT inhibitor with IC50 of 11 nM for [14C]-lactate influx; new antitumor treatment targeting lactate transport in Y cells.		Mitochondrial Metabolism , Monocarboxylate transporter
T9232	Mitochondrial fusion promoter M1		Mitochondrial Metabolism
	Mitochondrial fusion promoter M1, a modulator of mitochondrial dynamics, enhances mitochondrial function and cellular respiration, and has shown efficacy in reducing brain and cardiac damage in rats suffering from cardia...		Mitochondrial Metabolism
T9031	MCU-i4		Others , Mitochondrial Metabolism
	MCU-i4 is a novel negative modulator of the MCU, binding MICU1 and impairing muscle cell growth.		Others , Mitochondrial Metabolism
T15241	ER-000444793		Others , Mitochondrial Metabolism
	ER-000444793 is a potent mitochondrial permeability transition pore (mPTP) opening inhibitor and it also inhibits mPTP (IC50: 2.8 μM).		Others , Mitochondrial Metabolism
T14497	BAM 15		OXPHOS , Mitochondrial Metabolism
	BAM 15 is an uncoupler of mitochondrial protonophore.		OXPHOS , Mitochondrial Metabolism
T10706	CCI-006		Mitochondrial Metabolism
	CCI-006, a selective inhibitor and chemosensitizer for MLL-rearranged leukemia cells, disrupts mitochondrial respiration. This action leads to irreversible mitochondrial depolarization and triggers a pro-apoptotic unfold...		Mitochondrial Metabolism
T19428	Mito-TEMPO		Reactive Oxygen Species , Mitochondrial Metabolism
	Mito-TEMPO is a mitochondria-targeted superoxide dismutase mimetic. Mito-TEMPO scavenges superoxide and alkyl radicals and prevents mitochondrial oxidation, necrosis and apoptosis.		Reactive Oxygen Species , Mitochondrial Metabolism
T9169	MPP+ iodide		Mitochondrial Metabolism , Autophagy
	MPP+ iodide, the metabolite of a neurotoxin MPTP, causes symptom of Parkinson's disease (PD) in animal models by selectively destroying dopaminergic neurons in substantia nigra. MPP+ induces dopamine transporter (DAT) ex...		Mitochondrial Metabolism , Autophagy
T8732	CTPI-2		Others , Mitochondrial Metabolism
	CTPI-2 is an inhibitor of mitochondrial citrate carrier SLC25A1 with(KD : 3.5 μM). CTPI-2 inhibits glycolysis, PPARγ, and its downstream target the glucose transporter GLUT4. CTPI-2 exhibits anti-tumor activity.CTPI-2 ha...		Others , Mitochondrial Metabolism
T4639	Azemiglitazone	MSDC 0602	Mitochondrial Metabolism , mTOR
	Azemiglitazone (MSDC 0602) is an insulin sensitizer potentially for the treatment of diabetes.		Mitochondrial Metabolism , mTOR
T14140	Agaric acid	Agaricinic Acid	Mitochondrial Metabolism , AChR
	Agaricic acid is an adenine nucleotide translocase antagonist.It is obtained from various plants of the fungous tribe, i.e. Polyporus officinalis and Polyporus igniarius. Agaric acid (Agaricinic Acid) induces mitochondri...		Mitochondrial Metabolism , AChR
T7922	Kresoxim-Methyl		Others , Mitochondrial Metabolism , Antifungal
	Kresoxim-methyl is a strobilurin fungicide,inhibits conidial germination of V. inaequalis isolates from apple orchards .		Others , Mitochondrial Metabolism , Antifungal
T6157	Devimistat	CPI-613,CPI613,CPI 613,6,8-Bis(benzylthio)octanoic acid	Apoptosis , Dehydrogenase , Mitochondrial Metabolism
	Devimistat (6,8-Bis(benzylthio)octanoic acid) , a lipoate analog, inhibits mitochondrial enzymes pyruvate dehydrogenase (PDH) and α-ketoglutarate dehydrogenase, disrupts tumor cell mitochondrial metabolism. It has potent...		Apoptosis , Dehydrogenase , Mitochondrial Metabolism
T2498	Adjudin	AF-2364	Chloride channel , Mitochondrial Metabolism
	Adjudin (AF-2364) is a small molecule compound known to possess antispermatogenic function, attenuates microglia activation by suppression of the NF-κB pathway.		Chloride channel , Mitochondrial Metabolism